Prema mišljenju Harolda Frosta (1997), preduslov za nastanak osteoporoze je poremećaj receptora za mehaničko naprezanje u kostima – mehanostata, koji izmedju ostalog utiče i na proces mineralizacije kosti. 

Utvrdjeno je da se mehanostat može uspešno stimulisati i vibracionim stimulansom. Eksperimentalno su utvrdjena dva načina uticaja na koštanu gustinu vibracijama: 

• jedan je primenom visoke frekvencije i male amplitude koja stimuliše direktno kost (Rubin et al., 2002a, b; Ward et al., 2004; Rubin et al., 2004)
• drugi je indirektan, stimulacijom mišića vibracijama velike amplitude koji potom fiziološki stimulišu koštani sistem (Flieger et al., 1998; Verschueren et al., 2004; Rittweger & Felsenberg, 2004)

Kontrolisana i dozirana vibraciona terapija uz dodatak ostalih metoda treninga se značajno suprotstavlja osteoporozi.

Literatura

1. Frost HM. Defining osteopenias and osteoporoses: another view (with insights from a new paradigm). Bone 1997; 20:385-91.
2. Rubin C, Turner AS, Mallinckrodt C, Jerome C, McLeod K, Bain S. Mechanical strain, induced non-invasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Bone 2002;30:445-52.
3. Rubin C, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 2002;17:349-57.
4. Ward k, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res 2004;19:360-9.
5. Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res 2004;19:343-51.
6. Flieger J, Karachalios T, Khaldi L, Raptou P, Lyritis G. Mechanical stimulation in the form of vibration prevents postmenopausal bone loss in ovariectomized rats. Calcif Tissue Int 1998; 63:510-4. 
7. Verschueren SM, Roelants M, Delecluse C, Swinnen S, Vanderschueren D, Boonen S. Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J Bone Miner Res 2004; 19: 352-9.
8. Rittweger J, Felsenberg D. Resistive vibration exercise prevents bone loss during 8 weeks of strict bed rest in healthy male subjects: Results from the Berlin Bed Rest (BBR) study. J Bone Miner Res 2004; 19(Suppl. 1):1145.

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